Article
Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.
Scandinavian journal of gastroenterology - 1 Jan 2003
Caruso M G, Notarnicola M, Bifulco M, Laezza C, Guerra V, Altomare D F, Memeo V, Lorusso D, Demma I, Di Leo A
Abstract excerpt
BACKGROUND: The enzyme farnesyltransferase has emerged as an important target for anti-cancer therapies. Farnesyltransferase inhibitors have been introduced in clinical trials of subjects with colorectal cancer. We investigated Farnesyltransferase activity, beta-subunit Farnesyltransferase protein expression and its mRNA in patients with colorectal cancer and its relationship with clinicopathological features and...
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