Article
A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo.
Virology - 10 Apr 2007
Pöhlmann Stefan, Münch Jan, Aziz Sheriff, Reeves Jacqueline D, Otto Claas, Leslie George J, Hofmann Heike, Puffer Bridget A, Baribaud Frédéric, Marzi Andrea, Gramberg Thomas, Chen Zhiwei, Stolte Nicole, Haaft Peter Ten, Heeney Jonathan L, Stahl-Hennig Christiane, Mätz-Rensing Kerstin, Schneider Thomas, Doms Robert W, Kirchhoff Frank
Abstract excerpt
Sexually transmitted HIV-1 strains utilize the chemokine receptor CCR5 for viral entry and inhibitors targeting this coreceptor offer great promise for antiretroviral therapy. They also raise the question, however, whether viral variants exhibiting altered coreceptor interactions and resistance against these antiviral agents might still be pathogenic. In the present study, we analyzed a SIVmac239 envelope (Env)...
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