Article
Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study.
American journal of medical genetics - 9 Oct 2000
Horowitz R, Kotler M, Shufman E, Aharoni S, Kremer I, Cohen H, Ebstein R P
Abstract excerpt
A previous case control study by Vandenbergh et al. [1997: Am J Med Genet 74:439-442] showed an association between the high activity catechol O-methyltransferase (COMT) polymorphism and polysubstance abuse in a group of North American subjects. In the current study we confirm these results by genotyping 38 Israeli heroin addicts and both parents using a robust family-based haplotype relative risk (HRR) strategy....
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