Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification

Abstract excerpt

Reciprocal gene activation and restriction during cell type differentiation from a common lineage is a hallmark of mammalian organogenesis. A key question, then, is whether a critical transcriptional activator of cell type-specific gene targets can also restrict expression of the same genes in other cell types. Here, we show that whereas the pituitary-specific POU domain factor Pit-1 activates growth hormone gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Hypoxia, and Metabolism
• Share to Growth Hormone and Insulin-like Growth Factors
• Share to TGF-β signaling in diseases