Article
Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer.
Human & experimental toxicology - 1 Jul 1997
Harrison D J, Cantlay A M, Rae F, Lamb D, Smith C A
Abstract excerpt
1. Genetic variation at the glutathione S-transferase M1 locus (GSTM1) has been associated with a number of apparently unrelated cancers, including lung cancer. Emphysema is a common lung disease often found concomitant with lung cancer. Both emphysema and lung cancer may result from chemical and oxidative damage caused by reactive species present in cigarette smoke or released from neutrophils recruited...
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