Article
Expression and therapeutic response related to apolipoprotein E polymorphism in primary biliary cirrhosis.
Journal of hepatology - 1 Jul 1997
Vuoristo M, Färkkilä M, Gylling H, Karvonen A L, Leino R, Lehtola J, Makinen J, Mattila J, Tilvis R, Miettinen T A
Abstract excerpt
BACKGROUND/AIMS/METHODS: Apolipoprotein E polymorphism, affecting intestinal absorption and biliary secretion of bile acids, might also contribute to the variable course and response to drug treatment of primary biliary cirrhosis. To test this possibility, we studied the apo E gene frequency, and the expression and response to drug therapy in different apo E isoforms of 88 patients with primary biliary cirrhosis,...
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