Article
The immunophenotype of blast transformation of chronic myelogenous leukemia: a high frequency of mixed lineage phenotype in "lymphoid" blasts and A comparison of morphologic, immunophenotypic, and molecular findings.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 1998
Khalidi H S, Brynes R K, Medeiros L J, Chang K L, Slovak M L, Snyder D S, Arber D A
Abstract excerpt
Immunophenotypic studies have a limited role in the diagnosis of chronic myelogenous leukemia (CML) but are increasingly being used in CML blast transformation (BT). Determination of the cell lineage of CML blasts is clinically important because patients with lymphoid blast transformation have a...
Topics
- Adult
- Aged
- Antigens, CD
- Antigens, Neoplasm
- B-Lymphocytes
- Female
- Flow Cytometry
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Hematopoietic Stem Cells
- Humans
- Immunophenotyping
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphocyte Activation