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Article

Pathobiology of lymphoid and myeloid blast crisis and management issues.

Hematology. American Society of Hematology. Education Program - 1 Jan 2005

Ilaria Robert L

Abstract excerpt

Despite recent improvements in the treatment of early-stage disease, the blastic phase of chronic myeloid leukemia (CML) remains a therapeutic challenge. For imatinib-naïve patients, imatinib provided encouraging hematologic and cytogenetic benefits; however, the vast majority of CML blast crisis cases today arise in patients already on imatinib-based therapy. Clonal evolution and duplication of the Philadelphia...

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Identifiers

PMID: 16304379
DOI: 10.1182/asheducation-2005.1.188

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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