Article
Genetic heterogeneity in blast crisis of chronic myelocytic leukemia.
Leukemia research - 1 Jan 1990
Ikeda T, Kita K, Miwa H, Kawakami K, Anazawa H, Ohno T, Nosaka T, Hatanaka M, Honjo T, Shirakawa S
Abstract excerpt
Fourteen patients with lymphoid and mixed blast crisis (BC) of chronic myelocytic leukemia were studied by immunophenotyping and genotyping. Rearrangements of immunoglobulin heavy chain (IgH), T-cell receptor (TcR) gamma and TcR beta genes were detected in all 14, in nine and in four patients, re...
Topics
- Antigens, Differentiation
- Blast Crisis
- Blotting, Southern
- Gene Rearrangement
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Genes, Immunoglobulin
- Genotype
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Phenotype