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Article

Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Zhang Shuangmin, Konstantinidis Diamantis G, Yang Jun-Qi, Mizukawa Benjamin, Kalim Khalid, Lang Richard A, Kalfa Theodosia A, Zheng Yi, Guo Fukun

Abstract excerpt

Thymocyte development is regulated by complex signaling pathways. How these signaling cascades are coordinated remains elusive. RhoA of the Rho family small GTPases plays an important role in actin cytoskeleton organization, cell adhesion, migration, proliferation, and survival. Nonetheless, the physiological function of RhoA in thymocyte development is not clear. By characterizing a conditional gene targeting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 25398325
DOI: 10.4049/jimmunol.1400839
PMCID: PMC4258484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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