Article
Mechanisms of retroviral mutation.
Trends in microbiology - 1 Jan 1996
Preston B D, Dougherty J P
Abstract excerpt
Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that introduce base substitutions, frame shifts, genetic rearrangements and hypermutations.
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