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Article

Yeast DNA ligase IV mediates non-homologous DNA end joining.

Nature - 31 Jul 1997

Wilson T E, Grawunder U, Lieber M R

Abstract excerpt

The discovery of homologues from the yeast Saccharomyces cerevisiae of the human Ku DNA-end-binding proteins (HDF1 and KU80) has established that this organism is capable of non-homologous double-strand end joining (NHEJ), a form of DNA double-strand break repair (DSBR) active in mammalian V(D)J recombination. Identification of the DNA ligase that mediates NHEJ in yeast will help elucidate the function of the...

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PMID: 9242411
DOI: 10.1038/41365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yeast DNA ligase IV mediates non-homologous DNA end joining.PMID 9242411Read ↗

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks.Semantic proximity Read ↗

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.Semantic proximity Read ↗

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian CellsSemantic proximity Read ↗

Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.Semantic proximity Read ↗

Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.Semantic proximity Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining.Semantic proximity Read ↗

Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain.Semantic proximity Read ↗

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.Semantic proximity Read ↗

DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster.Semantic proximity Read ↗

Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast.Semantic proximity Read ↗

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