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Article

Inverse associations of human leukocyte antigen and malaria parasite types in two West African populations.

Infection and immunity - 1 Feb 2005

Young Karen, Frodsham Angela, Doumbo Ogobara K, Gupta Sunetra, Dolo Amagana, Hu Jiang Ting, Robson Kathryn J H, Crisanti Andrea, Hill Adrian V S, Gilbert Sarah C

Abstract excerpt

Differences in allelic associations between populations continue to cause difficulties in the mapping and identification of susceptibility genes for complex polygenic diseases. Although well recognized, the basis of such interpopulation differences is poorly understood. We present an example of an inverse allelic association of an immune response genotype to an infectious disease in two neighboring West African...

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Identifiers

PMID: 15664937
DOI: 10.1128/IAI.73.2.953-955.2005
PMCID: PMC546931

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