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Article

AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency.

The journal of gene medicine - 1 Aug 2009

Vaessen Stefan F C, Veldman Robert Jan, Comijn Elisabeth M, Snapper Jolanda, Sierts Jeroen A, van den Oever Karin, Beattie Stuart G, Twisk Jaap, Kuivenhoven Jan Albert

Abstract excerpt

BACKGROUND: Inherited apolipoprotein (Apo) A-I deficiency is an orphan disorder characterized by high-density lipoprotein (HDL)-cholesterol deficiency and premature atherosclerosis. Constitutive over-expression of ApoA-I might provide a means to treat this disease. The present study provides a comprehensive evaluation of adeno-associated virus (AAV)-mediated ApoA-I gene delivery to express human (h)ApoA-I and...

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Identifiers

PMID: 19431216
DOI: 10.1002/jgm.1344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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