Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele.

doi:10.1084/jem.177.1.135

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Article

Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele.

The Journal of experimental medicine - 1 Jan 1993

Charmley P, Wang K, Hood L, Nickerson D A

Abstract excerpt

Germline variation in genes that encode the human T cell receptors (TCRs) may have an important influence in shaping the immune T cell repertoire. In this report we describe a frequent null allele of the human V beta 18 gene, resulting from a nucleotide substitution that creates a stop codon (CGA...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Codon
Genetic Linkage
Humans
Molecular Sequence Data
Polymorphism, Genetic
RNA
Receptors, Antigen, T-Cell, alpha-beta

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