Article
Tissue-specific characteristics of cytotoxic graft-infiltrating T cells during renal allograft rejection.
Transplantation - 15 Jul 1997
Deckers J G, Boonstra J G, Van der Kooij S W, Daha M R, Van der Woude F J
Abstract excerpt
BACKGROUND: The alloresponse after renal transplantation was studied using alloreactive T cells generated in vivo (from renal biopsies) and in vitro (from mixed kidney lymphocyte cultures). METHODS: Tissue specificity of graft-infiltrating T cells (GIC) was investigated using donor-derived proximal tubular epithelial cells (PTEC) and splenocytes as targets in cytotoxicity assays. RESULTS: The outgrowth of...
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