Article
Predominant Th1 cell infiltration in acute rejection episodes of human kidney grafts.
Kidney international - 1 Jun 1997
D'Elios M M, Josien R, Manghetti M, Amedei A, de Carli M, Cuturi M C, Blancho G, Buzelin F, del Prete G, Soulillou J P
Abstract excerpt
T-cells and their cytokines are thought to play a major role in the genesis of cellular infiltration and rejection in human kidney allografts. Production of Th1 (IFN-gamma) and Th2-type (IL-4 and IL-5) cytokines was assessed in a large series of T-cell clones, derived from core biopsies of kidney grafts in 10 patients with acute interstitial grade I/II rejection (AIR), 6 patients with a histology of "borderline...
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