Article
CD103+ CTL accumulate within the graft epithelium during clinical renal allograft rejection.
Transplantation - 15 Nov 2001
Hadley G A, Charandee C, Weir M R, Wang D, Bartlett S T, Drachenberg C B
Abstract excerpt
BACKGROUND: We have previously reported that activated CD8+TCRalphabeta+ cells that express high levels of the beta7 integrin CD103 (formerly alphaE, MLA) are present at the graft site during clinical renal allograft rejection. This observation potentially provides new insight into the mechanisms underlying renal allograft destruction because the ligand of CD103 is the epithelial cell-specific molecule...
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