Article
The development of primed/memory CD8+ lymphocytes in vitro and in rejecting kidneys after transplantation.
Clinical and experimental immunology - 1 Aug 1990
Akbar A N, Amlot P L, Timms A, Lombardi G, Lechler R, Janossy G
Abstract excerpt
In normal individuals, 80 +/- 5% of circulating CD8+ T cells express CD45RA, and 20 +/- 7% of these cells express CD45R0 antigens. After activation, CD8+ cells expressing CD45RA decrease to 56-67% while those expressing CD45R0 increase to 38-67%. Although precursors of alloantigen-specific cytotoxic T cells were found in both CD8+, CD45RA+ and CD8+, CD45R0+ subsets, the specific effector cells were exclusively...
Topics
- Antibodies, Monoclonal
- Antigens, Differentiation
- Antigens, Differentiation, T-Lymphocyte
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- Cytotoxicity Tests, Immunologic
- Graft Rejection
- Histocompatibility Antigens
- Humans
- Immunologic Memory