OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime.

doi:10.1111/j.1574-6968.1997.tb10439.x

Back to search

Article

OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime.

FEMS microbiology letters - 15 Jul 1997

Bonomo R A, Rudin S D, Shlaes D M

Abstract excerpt

The Asp179Gly mutant of the OHIO-1 beta-lactamase, an SHV enzyme, was constructed to investigate the effect of disruption of the omega loop on beta-lactamase activity in this class A enzyme. In Escherichia coli DH5 alpha the strain possessing the Asp179Gly mutation of the OHIO-1 beta-lactamase de...

Topics

Aspartic Acid
Ceftazidime
Cephalosporin Resistance
Cephalosporins
Escherichia coli
Kinetics
Microbial Sensitivity Tests
Mutation
Penicillins
beta-Lactamases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.