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Article

Unexpected advanced generation cephalosporinase activity of the M69F variant of SHV beta-lactamase.

The Journal of biological chemistry - 6 Dec 2002

Helfand Marion S, Hujer Andrea M, Sönnichsen Frank D, Bonomo Robert A

Abstract excerpt

Infections with bacteria that contain hydrolytic beta-lactamase enzymes are becoming a serious problem in the United States. Mutations at Met-69, an amino acid proximal to the active site Ser-70 in the TEM-1 and SHV-1 beta-lactamases, have emerged as a puzzling cause of bacterial resistance to in...

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PMID: 12354765
DOI: 10.1074/jbc.M207271200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12354765-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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