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Article

Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology.

Journal of lipid research - 1 Nov 2004

Bellamine Aouatef, Lepesheva Galina I, Waterman Michael R

Abstract excerpt

14alpha-Demethylase (CYP51) is a key enzyme in all sterol biosynthetic pathways (animals, fungi, plants, protists, and some bacteria), catalyzing the removal of the C-14 methyl group following cyclization of squalene. Based on mutations found in CYP51 genes from Candida albicans azole-resistant isolates obtained after fluconazole treatment of fungal infections, and using site-directed mutagenesis, we have found...

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Identifiers

PMID: 15314102
DOI: 10.1194/jlr.M400239-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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