Article
The Roles of Bcl-XL and Apopain in the Control of Erythropoiesis by Erythropoietin
15 Jul 1997
Abstract excerpt
Erythropoietin (EP) is required by late-stage erythroid progenitor cells to prevent apoptosis. Several lines of evidence suggest that it is this action of EP that regulates erythrocyte production in vivo. To study the control of apoptosis in mouse and human erythroblasts, the expression of members of the Bcl-2 family of proteins and the expression and activation of the apoptosis-linked cysteine protease...
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