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Article

Caspase-3 has a nonapoptotic function in erythroid maturation

23 Feb 2004

Abstract excerpt

Caspase-3 plays a central role in apoptosis. It is also activated in normal erythropoiesis, with its activity peaking early during development (erythroid colony-forming unit [CFU-E] stage). In the present study, we have reduced the expression and subsequent enzymatic activity of caspase-3 by transfection of small interfering RNA (siRNA) directed to caspase-3 in a differentiating human erythroid culture system. We...

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PMID: 14976035
DOI: 10.1182/blood-2003-09-3362

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