A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.

doi:10.1128/JVI.71.8.6094-6099.1997

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Article

A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.

Journal of virology - 1 Aug 1997

Alexander L, Du Z, Rosenzweig M, Jung J U, Desrosiers R C

Abstract excerpt

A T-lymphoid cell line termed 221 was derived from a rhesus monkey infected with herpesvirus saimiri. Growth of 221 cells was dependent on the addition of interleukin-2 (IL-2) to the culture medium. In the absence of IL-2, 221 cells arrested in G0-G1 but did not die. Simian immunodeficiency virus...

Topics

Alleles
Animals
Cell Line
Genes, nef
HIV
Interleukin-2
Lymphocyte Activation
Macaca mulatta
Simian Immunodeficiency Virus
Virus Replication

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