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Article

HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages.

Nature medicine - 1 Sept 1999

Swingler S, Mann A, Jacqué J, Brichacek B, Sasseville V G, Williams K, Lackner A A, Janoff E N, Wang R, Fisher D, Stevenson M

Abstract excerpt

Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to promote the infection of macrophages. Here we demonstrate that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory proteins 1alpha and 1beta, by HIV-1-infected macrophages. Adenovirus-mediated expression of Nef...

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Share to Chemokine CCL4
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalitis, Viral

Share to Gene Products, nef

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Share to Macrophage Inflammatory Proteins

Share to nef Gene Products, Human Immunodeficiency Virus

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Source

Open in PubMed Open full text

Identifiers

PMID: 10470075
DOI: 10.1038/12433
PMCID: PMC9513713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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