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Article

Arginine-481 mutation abolishes ligand-binding of the AMPA-selective glutamate receptor channel alpha1-subunit.

Brain research. Molecular brain research - 1 Jul 1997

Kawamoto S, Uchino S, Xin K Q, Hattori S, Hamajima K, Fukushima J, Mishina M, Okuda K

Abstract excerpt

Arginine-481 is located in the putative agonist-binding region preceding the putative transmembrane segment M1 of the alpha1-subunit of the AMPA-selective glutamate receptor (GluR) channel. This amino acid is completely conserved among GluR proteins. A site-directed mutagenesis study using a baculovirus expression system showed that substitution of glutamate, glutamine and lysine for arginine-481 of the...

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PMID: 9221933
DOI: 10.1016/s0169-328x(97)00103-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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