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Article

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor.

Molecular and cellular endocrinology - 10 Feb 2011

Wootten Denise L, Simms John, Massoura Amelia J, Trim Julie E, Wheatley Mark

Abstract excerpt

Defining key differences between agonist and antagonist binding to hormone receptors is important and will aid rational drug design. Glu(1.35) in transmembrane helix 1 (TM1) of the human oxytocin receptor (OTR) is absolutely conserved in all OTRs cloned to date. We establish that Glu(1.35) is critical for high affinity binding of agonists (full and partial) but is not required for antagonist binding (peptide or...

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Identifiers

PMID: 21130837
DOI: 10.1016/j.mce.2010.11.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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