Article
The CAG/polyglutamine tract diseases: gene products and molecular pathogenesis.
Brain pathology (Zurich, Switzerland) - 1 Jul 1997
Koshy B T, Zoghbi H Y
Abstract excerpt
In the past few years, a new type of genetic mutation, expansion of trinucleotide repeats, has been shown to cause neurologic disease. This new class of mutations was first identified in 1991 as the underlying genetic defect in spinal and bulbar muscular atrophy and the fragile X syndrome, and in recent years, trinucleotide repeat expansions have been found to be the causative mechanism in 10 other neurologic...
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