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Article

The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.

British journal of haematology - 1 Jun 1997

Tosetto A, Missiaglia E, Frezzato M, Rodeghiero F

Abstract excerpt

We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in increased levels of plasma homocysteine, may be a putative risk factor for venous thromboembolism (VT). Sixty-five cases of VT and 130 controls, both identified within the framework of an epidemiologic survey on thrombophilia, the Vicenza Thrombophilia and Arteriosclerosis (VITA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9217179
DOI: 10.1046/j.1365-2141.1997.1422957.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.PMID 9217179Read ↗

Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.Semantic proximity Read ↗

The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.Semantic proximity Read ↗

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The VITA project: prothrombin G20210A mutation and venous thromboembolism in the general population.Semantic proximity Read ↗

C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.Semantic proximity Read ↗

No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study.Semantic proximity Read ↗

Major and potential prothrombotic genotypes in a cohort of patients with venous thromboembolism.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease.Semantic proximity Read ↗

Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease.Semantic proximity Read ↗

THROMBOTIC RISK EVALUATION OF TWO METHYLENETETRAHYDROFOLATE REDUCTASE MUTATIONS C677t AND A1298c IN VENOUS THROMBOEMBOLISM.Semantic proximity Read ↗

Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).Semantic proximity Read ↗

Lack of association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece.Semantic proximity Read ↗

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