Article
A second mutation in the methylenetetrahydrofolate reductase gene and the risk of venous thrombotic disease.
British journal of haematology - 1 May 1999
Franco R F, Morelli V, Lourenço D, Maffei F H, Tavella M H, Piccinato C E, Thomazini I A, Zago M A
Abstract excerpt
We assessed the effect of a recently described mutation in the MTHFR gene (1298 A --> C) on the risk of deep venous thrombosis (DVT) by determining its prevalence in 190 patients with verified DVT and in age-, race- and gender-matched controls. MTHFR 1298 A --> C was found in 42.1% of patients and in 41.1% of controls. The OR for venous thrombosis was 1.07 (95% CI 0.70-1.65) for heterozygotes and 0.83 (95% CI...
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