Article
C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.
Haematologica - 1 Sept 1999
Gemmati D, Serino M L, Trivellato C, Fiorini S, Scapoli G L
Abstract excerpt
BACKGROUND AND OBJECTIVE: Hyperhomocysteinemia, due to a combination of genetic and environmental factors, is considered to be a risk factor for vascular disease. Individuals with the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR), due to homozygous C677T MTHFR gene mutation, have significantly raised plasma levels of homocysteine and may be at increased risk of vascular disease. However, it...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Substitution
- Arterial Occlusive Diseases
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Hyperhomocysteinemia
- Male