Article
The mottled gene is the mouse homologue of the Menkes disease gene.
Nature genetics - 1 Apr 1994
Levinson B, Vulpe C, Elder B, Martin C, Verley F, Packman S, Gitschier J
Abstract excerpt
The mottled mouse has been proposed as an animal model for Menkes disease, an X-linked disorder of copper transport. The recent isolation of a copper-transporting ATPase gene responsible for Menkes disease has allowed us to test this hypothesis. Here we report the isolation and sequence of the mouse homologue of this gene. We show that two mottled (Mo) alleles, dappled (Modp) and blotchy (Moblo), have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.