Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease.

Genomics - 1 Feb 2006

Mototani Yasumasa, Miyoshi Ichiro, Okamura Tadashi, Moriya Takuya, Meng Yan, Yuan Pei Xiang, Kameo Satomi, Kasai Noriyuki

Abstract excerpt

Mottled Tohoku (Atp7a(Mo-Tohm) or Mo(Tohm)) is an X-linked mutation with mottled pigmentation in heterozygous (Mo(Tohm)/+) females and is embryonic lethal at E11 in hemizygous (Mo(Tohm)/Y) males. Copper levels were low in the brain and high in the intestine of Mo(Tohm) mice. Two congenic strains with ICR or C57BL/6 (B6) background were produced for genetic and phenotypic analyses and revealed that Mo(Tohm)/+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cation Transport Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Copper-Transporting ATPases

Share to Genes, Lethal

Share to In Situ Nick-End Labeling

Share to Menkes Kinky Hair Syndrome

Share to Mice, Mutant Strains

Share to Transgenes

Source

Identifiers

PMID: 16338116
DOI: 10.1016/j.ygeno.2005.09.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease.PMID 16338116Read ↗

Molecular and biochemical characterization of Mottled-dappled, an embryonic lethal Menkes disease mouse model.Semantic proximity Read ↗

Molecular genetics and pathophysiology of Menkes disease.Semantic proximity Read ↗

[Mice with mottled mutation--a model for defective copper metabolism in humans].Semantic proximity Read ↗

Mutation spectrum of ATP7A, the gene defective in Menkes disease.Semantic proximity Read ↗

Autonomous requirements of the Menkes disease protein in the nervous system.Semantic proximity Read ↗

Menkes disease.Semantic proximity Read ↗

Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease.Semantic proximity Read ↗

Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis.Semantic proximity Read ↗

Intragenic deletions at Atp7a in mouse models for Menkes disease.Semantic proximity Read ↗

Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease.Semantic proximity Read ↗

Menkes disease.Semantic proximity Read ↗

[From gene to disease; Menkes disease: copper deficiency due to an ATP7A-gene defect].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.