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Article

Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease.

Human molecular genetics - 1 Jul 1997

Grimes A, Hearn C J, Lockhart P, Newgreen D F, Mercer J F

Abstract excerpt

The brindled mouse mutant (Mo(br)) is the closest animal model of the human genetic copper deficiency, Menkes disease, which is presumed to be due to a mutation at the X-linked mottled locus (Mo). The mutant mice are hypopigmented and die at around 15 days after birth, but can be saved by treatment with copper before the 10th postnatal day. Menkes disease has been shown to be due to mutations of the gene ATP7A...

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Identifiers

PMID: 9215672
DOI: 10.1093/hmg/6.7.1037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease.PMID 9215672Read ↗

Intracellular localization and loss of copper responsiveness of Mnk, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants.Semantic proximity Read ↗

Phenotypic and genetic characterization of the Atp7a(Mo-Tohm) mottled mouse: a new murine model of Menkes disease.Semantic proximity Read ↗

Correction of a mouse model of Menkes disease by the human Menkes gene.Semantic proximity Read ↗

The mottled gene is the mouse homologue of the Menkes disease gene.Semantic proximity Read ↗

Molecular and biochemical characterization of Mottled-dappled, an embryonic lethal Menkes disease mouse model.Semantic proximity Read ↗

Autonomous requirements of the Menkes disease protein in the nervous system.Semantic proximity Read ↗

Intragenic deletions at Atp7a in mouse models for Menkes disease.Semantic proximity Read ↗

ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease mouse model.Semantic proximity Read ↗

Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).Semantic proximity Read ↗

Molecular genetics and pathophysiology of Menkes disease.Semantic proximity Read ↗

Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease.Semantic proximity Read ↗

Menkes syndrome and animal models.Semantic proximity Read ↗

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