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Article

The toxic milk mouse is a murine model of Wilson disease.

Human molecular genetics - 1 Oct 1996

Theophilos M B, Cox D W, Mercer J F

Abstract excerpt

Wilson disease (WD) is an autosomal recessive defect of copper transport characterized by massive accumulation of copper in the liver, which can lead to liver failure. Mutations in a copper transporting ATPase (WND or ATP7B) have been shown to cause the disease. The toxic milk mouse mutant (tx) accumulates copper in the liver in a manner similar to that observed in patients with WD. However, some physiological...

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Identifiers

PMID: 8894697
DOI: 10.1093/hmg/5.10.1619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The toxic milk mouse is a murine model of Wilson disease.PMID 8894697Read ↗

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase.Semantic proximity Read ↗

Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant.Semantic proximity Read ↗

Toxic milk mice models of Wilson's disease.Semantic proximity Read ↗

Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transportersSemantic proximity Read ↗

A Gene Therapy Approach to Improve Copper Metabolism and Prevent Liver Damage in a Mouse Model of Wilson DiseaseSemantic proximity Read ↗

Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.Semantic proximity Read ↗

Animal models of Wilson disease.Semantic proximity Read ↗

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.Semantic proximity Read ↗

Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation.Semantic proximity Read ↗

Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.Semantic proximity Read ↗

The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene.Semantic proximity Read ↗

Wilson disease: intersecting DNA methylation and histone acetylation regulation of gene expression in a mouse model of hepatic copper accumulationSemantic proximity Read ↗

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