Article
Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant.
Biochemical and biophysical research communications - 9 Mar 2001
Voskoboinik I, Greenough M, La Fontaine S, Mercer J F, Camakaris J
Abstract excerpt
The Wilson protein (WND; ATP7B) is an essential component of copper homeostasis. Mutations in the ATP7B gene result in Wilson disease, which is characterised by hepatotoxicity and neurological disturbances. In this paper, we provide the first direct biochemical evidence that the WND protein functions as a copper-translocating P-type ATPase in mammalian cells. Importantly, we have shown that the mutation of the...
Topics
- Adenosine Triphosphatases
- Animals
- Biological Transport
- CHO Cells
- Carrier Proteins
- Cation Transport Proteins
- Copper
- Copper-Transporting ATPases
- Cricetinae
- DNA, Recombinant
- Kinetics