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Article

Early growth response gene 1 (<i>EGR1</i>) is deleted in estrogen receptor‐negative human breast carcinoma

5 Jul 2005

Abstract excerpt

BACKGROUND: Patients with estrogen receptor (ER)-positive and ER-negative breast carcinomas differ in terms of disease progression, treatment regimens, and prognosis. The mechanism underlying the biologic differences of the two groups is understood poorly. Array comparative genome hybridization (CGH) on breast carcinoma subtypes demonstrated a consistent association between loss in regions of chromosome 5q and...

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Identifiers

PMID: 15999367
DOI: 10.1002/cncr.21262

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Research trail→

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Early growth response gene 1 (<i>EGR1</i>) is deleted in estrogen receptor‐negative human breast carcinomaPMID 15999367Read ↗

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The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.Semantic proximity Read ↗

Ionizing radiation activates transcription of the EGR1 gene via CArG elements.Semantic proximity Read ↗

Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues.Semantic proximity Read ↗

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.Semantic proximity Read ↗

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