Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leishmania infantum amastigotes resistant to nitric oxide cytotoxicity: Impact on in vitro parasite developmental cycle and metabolic enzyme activities.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 May 2006

Holzmuller Philippe, Hide Mallorie, Sereno Denis, Lemesre Jean-Loup

Abstract excerpt

Nitric oxide (NO) has been demonstrated to be the principal effector molecule mediating intracellular killing of Leishmania. The free radical characteristic of NO prevented direct induction of resistance in Leishmania wild-type parasites. Starting from the previous observation that antimony-resistant amastigotes of Leishmania infantum were not affected by NO-induced apoptotic death, we used a continuous NO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aconitate Hydratase
Share to Leishmania infantum

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Life Cycle Stages

Share to Macrophage Activation

Share to Macrophages, Peritoneal

Share to Nitric Oxide

Share to Nitrites

Share to Phosphogluconate Dehydrogenase

Source

Identifiers

PMID: 15905133
DOI: 10.1016/j.meegid.2005.03.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leishmania infantum amastigotes resistant to nitric oxide cytotoxicity: Impact on in vitro parasite developmental cycle and metabolic enzyme activities.PMID 15905133Read ↗

Phenotypical characteristics, biochemical pathways, molecular targets and putative role of nitric oxide-mediated programmed cell death in Leishmania.Semantic proximity Read ↗

The Anti‐Parasitic Effects of Nitric OxideSemantic proximity Read ↗

Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility.Semantic proximity Read ↗

Naturally occurring triggers that induce apoptosis-like programmed cell death in Plasmodium berghei ookinetes.Semantic proximity Read ↗

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantumSemantic proximity Read ↗

An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.Semantic proximity Read ↗

Alpha-difluoromethylornithine-resistant cell lines obtained after one-step selection of Leishmania mexicana promastigote cultures.Semantic proximity Read ↗

Experimental studies on the evolution of antimony-resistant phenotype during the in vitro life cycle of Leishmania infantum: implications for the spread of chemoresistance in endemic areas.Semantic proximity Read ↗

Efficacy of second line drugs on antimonyl-resistant amastigotes of Leishmania infantum.Semantic proximity Read ↗

Unveiling drug-tolerant and persister-like cells in Leishmania braziliensis lines derived from patients with cutaneous leishmaniasisSemantic proximity Read ↗

Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony.Semantic proximity Read ↗

Sodium Diethyldithiocarbamate antiparasitic activity against different <i>Trypanosoma cruzi</i> strains: Insights of its biological activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.