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Article

Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation

15 Jun 2002

Abstract excerpt

Incidence rates of follicular lymphoma (FL) inexplicably vary markedly between Western and Asian countries. A hallmark of FL is the bcl-2 translocation, characterized by 1 of 2 common breakpoints known as major breakpoint region (MBR) and minor cluster region (mcr). We analyzed previously published data to compare rates of bcl-2 translocation in FL across geographic regions. Available data from the literature...

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PMID: 12036852
DOI: 10.1182/blood.v99.12.4265

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