Article
The engagement of CD4 surface antigen in the HEL haemopoietic cell line up-regulates the transforming growth factor-beta1 (TGF-beta1) promoter activity.
British journal of haematology - 1 Jun 1997
Gibellini D, Celeghini C, Panaya R, Secchiero P, Capitani S, La Placa M, Zauli G
Abstract excerpt
In order to investigate the effect of CD4 engagement on the transforming growth factor beta1 (TGF-beta1) promoter activity in haemopoietic progenitors, HEL cells were transiently transfected with a plasmid vector containing -453/+11 nucleotides of the TGF-beta1 promoter fused with the bacterial chloramphenicol acetyltransferase (CAT) gene and then treated with various agonists. Both cross-linked CD4mAb and...
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