Article
Thymosin-alpha1 regulates MHC class I expression in FRTL-5 cells at transcriptional level.
European journal of immunology - 1 Mar 2000
Giuliani C, Napolitano G, Mastino A, Di Vincenzo S, D'Agostini C, Grelli S, Bucci I, Singer D S, Kohn L D, Monaco F, Garaci E, Favalli C
Abstract excerpt
In this study we examined the effect of the synthetic peptide thymosin-alpha1 (T(alpha)1) on MHC class I expression in FRTL-5 cells. Treatment with T(alpha)1 increased expression of MHC class I surface molecules and mRNA, which reached its peak (153 +/- 8 % of the control value) after 12 h. Chloramphenicol acetyltransferase (CAT) analysis, following transfection with a plasmid containing the regulatory sequence...
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