Article
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997
Herzig T C, Jobe S M, Aoki H, Molkentin J D, Cowley A W, Izumo S, Markham B E
Abstract excerpt
Hypertrophy of mammalian cardiac muscle is mediated, in part, by angiotensin II through an angiotensin II type1a receptor (AT1aR)-dependent mechanism. To understand how the level of AT1aRs is altered in this pathological state, we studied the expression of an injected AT1aR promoter-luciferase reporter gene in adult rat hearts subjected to an acute pressure overload by aortic coarctation. This model was validated...
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