Article
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Cancer research - 1 Oct 1992
Casero R A, Mank A R, Xiao L, Smith J, Bergeron R J, Celano P
Abstract excerpt
Our previous results from a limited number of cell lines have suggested that the bis(ethyl)polyamine analogues exert a phenotype-specific response in human lung cancer cells. In the present study, we have extended this work to analyze the response of the 4 major forms of human lung cancer to the...
Topics
- Acetyltransferases
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Cell Division
- Cell Survival
- Enzyme Induction
- Humans
- Lung Neoplasms
- Phenotype
- Polyamines
- RNA, Messenger
- Sensitivity and Specificity
- Spermine
- Tumor Cells, Cultured