The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity

Abstract excerpt

The cytotoxic activities and subcellular localizations of clinically used and synthetic analogues of the anthracycline family of chemotherapeutic agents were studied. The structures of the anthracycline derivatives affected their cytotoxicity and the time required for these compounds to exert cytotoxic effects on tumor cells. Fluorescent DNA intercalator displacement experiments demonstrated that there was no...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer therapeutics and mechanisms
• Share to Cancer Treatment and Pharmacology
• Share to Chemotherapy-induced cardiotoxicity and mitigation