Mechanisms of drug resistance in hematologic malignancies.

Article

Mechanisms of drug resistance in hematologic malignancies.

Seminars in hematology - 1 Oct 1997

Dalton W S

Abstract excerpt

Multiple cellular mechanisms contribute to the overall clinical drug-resistant phenotype of malignant cells. A major mechanism of drug resistance documented to occur in hematologic malignancies is overexprssion of the MDR-1 gene product, P-glycoprotein (P-gp). Drugs, called chemosensitizers, have...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Apoptosis
DNA Repair
Drug Resistance, Neoplasm
Hematologic Neoplasms
Humans
Phenotype

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