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Article

Isoform-specific modulation by apolipoprotein E of the activities of secreted beta-amyloid precursor protein.

Journal of neurochemistry - 1 Jul 1997

Barger S W, Mattson M P

Abstract excerpt

The genes for both the beta-amyloid precursor protein and apolipoprotein E (ApoE) have been linked to Alzheimer's disease. This connection suggests the possibility that these proteins interact physically or functionally. To explore this idea, we focused on the neuroprotective activity of secreted amyloid precursor protein (sAPP) and related signal transduction events. After coincubation with ApoE, sAPP exhibited...

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Identifiers

PMID: 9202294
DOI: 10.1046/j.1471-4159.1997.69010060.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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