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Article

Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors.

Seminars in immunology - 1 Jun 1997

Danska J S, Guidos C J

Abstract excerpt

V(D)J recombination generates a diverse array of antigen-binding specificities, but breakage and re-joining of DNA segments have grave implications for the maintenance of genomic stability and oncogenic risk. Exposure of eukaryotic cells to genotoxic agents activates a DNA damage checkpoint that induces cell-cycle arrest and DNA repair, or apoptosis. We discuss several lines of evidence implicating DNA-dependent...

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Identifiers

PMID: 9200331
DOI: 10.1006/smim.1997.0072

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors.PMID 9200331Read ↗

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ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responsesSemantic proximity Read ↗

Differential DNA Damage Response of Peripheral Blood Lymphocyte Populations.Semantic proximity Read ↗

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