Article
Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors.
Seminars in immunology - 1 Jun 1997
Danska J S, Guidos C J
Abstract excerpt
V(D)J recombination generates a diverse array of antigen-binding specificities, but breakage and re-joining of DNA segments have grave implications for the maintenance of genomic stability and oncogenic risk. Exposure of eukaryotic cells to genotoxic agents activates a DNA damage checkpoint that...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Nuclear
- Ataxia Telangiectasia
- Cell Cycle
- DNA Damage
- DNA Helicases
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Hematopoietic Stem Cells
- Humans
- Ku Autoantigen