Article
Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit.
The Journal of biological chemistry - 27 Jun 1997
Gibson R M, Ji-Buechler Y, Taylor S S
Abstract excerpt
Since a basic surface on the catalytic (C) subunit of cAMP-dependent protein kinase is important for binding to the regulatory (R) subunit, acidic residues in R were sought that might contribute to R-C interaction. Using differential labeling by a water-soluble carbodiimide (Buechler, T. A., and...
Topics
- Amino Acid Sequence
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit
- Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
- Cyclic AMP-Dependent Protein Kinases
- Hydrogen Bonding
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- Recombinant Proteins
- Static Electricity
- Structure-Activity Relationship