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Article

Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.

Biochemistry - 14 Mar 2017

P Barros Emília, Malmstrom Robert D, Nourbakhsh Kimya, Del Rio Jason C, Kornev Alexandr P, Taylor Susan S, Amaro Rommie E

Abstract excerpt

Close-range electrostatic interactions that form salt bridges are key components of protein stability. Here we investigate the role of these charged interactions in modulating the allosteric activation of protein kinase A (PKA) via computational and experimental mutational studies of a conserved basic patch located in the regulatory subunit's B/C helix. Molecular dynamics simulations evidenced the presence of an...

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Identifiers

PMID: 28221775
DOI: 10.1021/acs.biochem.6b01152
PMCID: PMC5495472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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